Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
5ht2b_human 451 C-term S => Ter stop gained 8.274e-06 1 120862 0 None None
5ht2b_human 444 C-term S => LysfsTer25 frameshift 3.305e-05 4 121036 0 None None
5ht2b_human 434 C-term R => Ter stop gained 2.477e-05 3 121124 0 None None
5ht2b_human 426 C-term K => Ter frameshift 1.65e-05 2 121200 0 None None
5ht2b_human 397 C-term C => Ter stop gained 8.242e-06 1 121324 0 None None
5ht2b_human 393 8.56x56 H8 R => Ter stop gained 1.649e-05 2 121304 0 None None
5ht2b_human 365 7.38x37 TM7 F => IlefsTer21 frameshift 8.255e-06 1 121134 0 None None
5ht2b_human 350 6.61x61 TM6 C => Ter stop gained 2.476e-05 3 121156 0 None None
5ht2b_human 337 6.48x48 TM6 W => Ter stop gained 2.473e-05 3 121322 0 None None SodiumPocket MicroSwitch LB (hydrophobic, Van der Waals)
5ht2b_human 303 ICL3 R => Ter stop gained 4.119e-05 5 121384 0 None None
5ht2b_human 296 ICL3 S => GlnfsTer31 frameshift 8.238e-06 1 121394 0 None None
5ht2b_human 288 ICL3 R => Ter stop gained 8.238e-06 1 121386 0 None None
5ht2b_human 246 5.67x67 TM5 K => Ter stop gained 0.0002802 34 121328 0 None None GP (contact)
5ht2b_human 239 5.60x60 TM5 L => SerfsTer34 frameshift 8.244e-06 1 121294 0 None None
5ht2b_human 224 5.45x46 TM5 A => LeufsTer10 frameshift 8.249e-06 1 121226 0 None None
5ht2b_human 207 45.50x50 ECL2 C => Ter stop gained 4.128e-05 5 121134 0 None None
5ht2b_human 113 2.63x62 TM2 L => AspfsTer5 frameshift 8.25e-06 1 121216 0 None None
5ht2b_human 87 2.37x37 TM2 Y => Ter stop gained 8.238e-06 1 121392 0 None None
5ht2b_human 35 N-term Q => Ter stop gained 1.648e-05 2 121396 0 None None
5ht2b_human 27 N-term I => SerfsTer17 frameshift 8.238e-06 1 121386 0 None None
5ht2b_human 20 N-term Q => Ter stop gained 0.001178 143 121350 1 None None
5ht2b_human 5 N-term Y => Ter stop gained 8.258e-06 1 121088 0 None None
5ht2b_human 4 N-term S => LeufsTer5 frameshift 8.261e-06 1 121052 0 None None
5ht2b_human 480 C-term Y => N missense 8.348e-06 1 119790 0 nan 0.901
5ht2b_human 477 C-term Q => E missense 1.667e-05 2 120012 0 nan 0.118
5ht2b_human 476 C-term E => G missense 1.666e-05 2 120060 0 nan 0.002
5ht2b_human 474 C-term T => S missense 1.664e-05 2 120228 0 nan 0.05
5ht2b_human 464 C-term L => F missense 8.294e-06 1 120570 0 nan 0.937
5ht2b_human 463 C-term T => M missense 0.0001825 22 120578 0 nan 0.958
5ht2b_human 463 C-term T => K missense 1.659e-05 2 120578 0 nan 0.097
5ht2b_human 459 C-term I => V missense 3.313e-05 4 120734 0 nan 0.01
5ht2b_human 458 C-term I => T missense 7.454e-05 9 120744 0 nan 0.0
5ht2b_human 457 C-term S => A missense 8.281e-06 1 120764 0 nan 0.021
5ht2b_human 454 C-term Q => R missense 8.275e-06 1 120848 0 nan 0.656
5ht2b_human 449 C-term R => Q missense 2.482e-05 3 120890 0 nan 0.004
5ht2b_human 446 C-term M => V missense 8.264e-06 1 121008 0 nan 0.0
5ht2b_human 443 C-term Q => H missense 8.262e-06 1 121034 0 nan 0.987
5ht2b_human 442 C-term Y => C missense 8.262e-06 1 121036 0 nan 0.037
5ht2b_human 439 C-term P => S missense 8.259e-06 1 121078 0 nan 0.226
5ht2b_human 434 C-term R => Q missense 9.082e-05 11 121118 0 nan 0.73
5ht2b_human 432 C-term G => R missense 8.255e-06 1 121144 0 nan 0.128
5ht2b_human 431 C-term H => R missense 8.254e-06 1 121156 0 nan 0.002
5ht2b_human 425 C-term S => F missense 8.25e-06 1 121210 0 nan 0.746
5ht2b_human 425 C-term S => C missense 8.25e-06 1 121210 0 nan 0.746
5ht2b_human 423 C-term E => D missense 8.25e-06 1 121212 0 nan 0.416
5ht2b_human 422 C-term A => T missense 8.249e-06 1 121220 0 nan 0.006
5ht2b_human 421 C-term M => V missense 0.00777 942 121240 35 nan 0.001
5ht2b_human 420 C-term P => S missense 8.248e-06 1 121240 0 1.0 0.001
5ht2b_human 418 C-term R => Q missense 3.299e-05 4 121250 0 nan 0.007
5ht2b_human 418 C-term R => W missense 0.0003299 40 121260 0 nan 0.591
5ht2b_human 412 C-term S => P missense 8.244e-06 1 121300 0 0.14 0.871 PTM (Phosphorylation)
5ht2b_human 411 C-term R => C missense 0.0001154 14 121312 0 0.25 0.0
5ht2b_human 408 C-term L => P missense 8.242e-06 1 121324 0 0.22 0.004
5ht2b_human 400 C-term R => Q missense 5.77e-05 7 121324 0 0.62 0.001
5ht2b_human 400 C-term R => W missense 1.648e-05 2 121326 0 0.02 0.0
5ht2b_human 394 8.57x57 H8 Y => C missense 3.297e-05 4 121316 0 0.0 0.999
5ht2b_human 393 8.56x56 H8 R => Q missense 0.0001649 20 121316 0 0.01 0.999
5ht2b_human 393 8.56x56 H8 R => P missense 0.0001072 13 121316 0 0.0 1.0
5ht2b_human 390 8.53x53 H8 A => T missense 0.0001979 24 121298 0 0.06 0.998
5ht2b_human 388 8.51x51 H8 R => W missense 0.001352 164 121258 2 0.0 1.0 GP (contact)
5ht2b_human 387 8.50x50 H8 F => S missense 2.474e-05 3 121274 0 0.0 0.983
5ht2b_human 386 8.49x49 H8 T => I missense 4.123e-05 5 121262 0 0.08 0.907 GP (contact)
5ht2b_human 381 7.54x54 TM7 T => I missense 1.65e-05 2 121240 0 0.0 0.999
5ht2b_human 381 7.54x54 TM7 T => N missense 8.248e-06 1 121240 0 0.0 0.999
5ht2b_human 372 7.45x45 TM7 S => P missense 2.476e-05 3 121184 0 0.0 0.991
5ht2b_human 366 7.39x38 TM7 V => A missense 8.256e-06 1 121130 0 0.01 0.91 LB (hydrophobic, Van der Waals)
5ht2b_human 365 7.38x37 TM7 F => L missense 1.651e-05 2 121134 0 0.0 0.999
5ht2b_human 354 7.27x26 TM7 N => Y missense 1.651e-05 2 121132 0 0.0 0.8
5ht2b_human 351 ECL3 D => E missense 5.778e-05 7 121156 0 0.76 0.026
5ht2b_human 350 6.61x61 TM6 C => F missense 8.255e-06 1 121142 0 0.0 1.0
5ht2b_human 347 6.58x58 TM6 L => S missense 1.651e-05 2 121174 0 0.65 0.003 LB (hydrophobic, Van der Waals)
5ht2b_human 342 6.53x53 TM6 I => V missense 1.65e-05 2 121248 0 0.14 0.581
5ht2b_human 329 6.40x40 TM6 V => L missense 8.239e-06 1 121370 0 0.0 0.999 GP (contact)
5ht2b_human 324 6.35x35 TM6 K => N missense 0.0009063 110 121376 0 0.0 1.0
5ht2b_human 319 6.30x30 TM6 E => K missense 2.471e-05 3 121386 0 0.0 1.0 SodiumPocket MicroSwitch
5ht2b_human 315 6.26x26 TM6 T => I missense 8.238e-06 1 121388 0 0.06 0.922 GP (contact)
5ht2b_human 308 ICL3 I => T missense 1.648e-05 2 121390 0 0.4 0.001
5ht2b_human 303 ICL3 R => Q missense 8.238e-06 1 121390 0 0.07 0.221
5ht2b_human 302 ICL3 M => T missense 4.119e-05 5 121392 0 0.75 0.002
5ht2b_human 292 ICL3 A => T missense 8.238e-06 1 121392 0 0.81 0.0
5ht2b_human 291 ICL3 K => T missense 1.648e-05 2 121394 0 0.35 0.053
5ht2b_human 288 ICL3 R => Q missense 1.648e-05 2 121390 0 0.3 0.007
5ht2b_human 287 ICL3 S => F missense 1.648e-05 2 121386 0 0.05 0.005
5ht2b_human 283 ICL3 M => T missense 6.59e-05 8 121396 0 0.12 0.032
5ht2b_human 282 ICL3 A => P missense 1.648e-05 2 121390 0 0.14 0.745
5ht2b_human 280 ICL3 K => T missense 0.001648 200 121386 2 0.19 0.915
5ht2b_human 278 ICL3 P => L missense 4.119e-05 5 121388 1 0.05 0.644
5ht2b_human 278 ICL3 P => A missense 8.238e-06 1 121388 0 0.1 0.21
5ht2b_human 276 ICL3 S => L missense 3.295e-05 4 121386 0 0.09 0.254
5ht2b_human 267 ICL3 V => A missense 8.238e-06 1 121386 0 0.11 0.086
5ht2b_human 266 ICL3 T => R missense 8.238e-06 1 121388 0 0.05 0.993
5ht2b_human 263 ICL3 T => N missense 8.238e-06 1 121382 0 0.11 0.016
5ht2b_human 261 ICL3 W => R missense 8.239e-06 1 121372 0 0.3 0.076
5ht2b_human 258 ICL3 R => H missense 2.472e-05 3 121362 0 0.03 0.284
5ht2b_human 258 ICL3 R => C missense 0.0001071 13 121368 0 0.02 0.284
5ht2b_human 256 ICL3 P => L missense 8.24e-06 1 121356 0 0.27 0.009
5ht2b_human 256 ICL3 P => S missense 8.24e-06 1 121360 0 0.64 0.006
5ht2b_human 255 5.76x76 TM5 P => T missense 8.241e-06 1 121350 0 0.32 0.243
5ht2b_human 250 5.71x71 TM5 L => V missense 1.648e-05 2 121344 0 0.06 0.11 GP (contact)
5ht2b_human 245 5.66x66 TM5 Q => R missense 8.243e-06 1 121310 0 0.6 0.004 GP (contact)
5ht2b_human 242 5.63x63 TM5 H => Y missense 8.244e-06 1 121302 0 0.09 0.417
5ht2b_human 237 5.58x58 TM5 Y => H missense 8.245e-06 1 121282 0 0.0 1.0 SodiumPocket MicroSwitch
5ht2b_human 218 5.39x40 TM5 M => K missense 8.252e-06 1 121188 0 0.15 0.006 LB (hydrophobic, Van der Waals)
5ht2b_human 217 5.38x39 TM5 F => L missense 8.252e-06 1 121190 0 0.0 0.999 LB (hydrophobic, Van der Waals, aromatic (face-to-face))
5ht2b_human 216 5.37x38 TM5 D => N missense 0.0001486 18 121132 0 1.0 0.001
5ht2b_human 215 5.36x37 TM5 G => S missense 1.651e-05 2 121162 0 nan 0.006
5ht2b_human 213 ECL2 R => C missense 1.651e-05 2 121168 0 0.06 0.79
5ht2b_human 211 ECL2 K => R missense 3.301e-05 4 121164 0 0.24 0.01
5ht2b_human 208 45.51x51 ECL2 V => L missense 0.002221 269 121110 4 0.64 0.002 LB (hydrophobic, Van der Waals)
5ht2b_human 205 ECL2 I => V missense 8.256e-06 1 121118 0 0.5 0.006
5ht2b_human 199 ECL2 V => M missense 8.264e-06 1 121004 0 0.16 0.029
5ht2b_human 198 ECL2 D => G missense 8.265e-06 1 120988 0 0.2 0.001
5ht2b_human 195 ECL2 I => T missense 8.267e-06 1 120962 0 0.01 0.049
5ht2b_human 193 4.63x64 TM4 K => E missense 8.269e-06 1 120930 0 0.17 0.328
5ht2b_human 186 4.56x56 TM4 I => T missense 0.0001159 14 120778 0 0.0 0.993
5ht2b_human 185 4.55x55 TM4 G => C missense 0.0001236 15 121394 0 0.1 0.513
5ht2b_human 184 4.54x54 TM4 I => T missense 1.648e-05 2 121396 0 0.01 0.048
5ht2b_human 173 4.43x43 TM4 F => L missense 0.002125 258 121400 0 1.0 0.001
5ht2b_human 170 4.40x40 TM4 A => V missense 1.647e-05 2 121402 0 0.02 0.886
5ht2b_human 169 4.39x39 TM4 R => Q missense 8.237e-06 1 121402 0 0.01 0.926
5ht2b_human 169 4.39x39 TM4 R => W missense 1.647e-05 2 121404 0 0.02 0.141
5ht2b_human 168 4.38x38 TM4 S => L missense 8.237e-06 1 121406 0 0.02 1.0
5ht2b_human 153 3.50x50 TM3 R => H missense 8.238e-06 1 121396 0 0.0 1.0 SodiumPocket MicroSwitch GP (contact)
5ht2b_human 151 3.48x48 TM3 V => A missense 2.471e-05 3 121402 0 0.01 0.509
5ht2b_human 147 3.44x44 TM3 C => R missense 8.238e-06 1 121388 0 0.0 1.0
5ht2b_human 144 3.41x41 TM3 M => T missense 0.000173 21 121378 1 0.0 0.85
5ht2b_human 144 3.41x41 TM3 M => V missense 8.239e-06 1 121376 0 0.01 0.454
5ht2b_human 142 3.39x39 TM3 S => F missense 2.472e-05 3 121364 0 0.0 1.0
5ht2b_human 141 3.38x38 TM3 A => T missense 1.648e-05 2 121360 0 0.0 1.0
5ht2b_human 140 3.37x37 TM3 T => I missense 2.472e-05 3 121356 0 0.0 1.0 LB (polar (hydrogen bond), Van der Waals)
5ht2b_human 138 3.35x35 TM3 F => S missense 8.241e-06 1 121338 0 0.0 1.0
5ht2b_human 136 3.33x33 TM3 V => I missense 2.473e-05 3 121312 0 0.05 0.999 LB (hydrophobic, Van der Waals)
5ht2b_human 128 3.25x25 TM3 C => G missense 8.248e-06 1 121238 0 0.0 1.0
5ht2b_human 126 3.23x23 TM3 V => G missense 8.253e-06 1 121166 0 0.54 0.006
5ht2b_human 120 23.49x49 ECL1 M => T missense 8.374e-06 1 119412 0 0.62 0.001
5ht2b_human 119 ECL1 A => V missense 8.435e-06 1 118550 0 0.47 0.006
5ht2b_human 119 ECL1 A => T missense 8.437e-06 1 118522 0 0.37 0.006
5ht2b_human 113 2.63x62 TM2 L => F missense 2.475e-05 3 121216 0 0.01 0.794
5ht2b_human 110 2.60x59 TM2 I => T missense 1.649e-05 2 121296 0 0.05 0.086
5ht2b_human 110 2.60x59 TM2 I => V missense 8.245e-06 1 121292 0 0.5 0.036
5ht2b_human 109 2.59x58 TM2 P => T missense 7.419e-05 9 121306 0 0.0 1.0
5ht2b_human 106 2.56x551 TM2 F => S missense 2.472e-05 3 121338 0 0.06 0.688
5ht2b_human 104 2.54x54 TM2 G => R missense 8.24e-06 1 121352 0 0.0 1.0
5ht2b_human 103 2.53x53 TM2 V => A missense 2.472e-05 3 121356 0 0.0 0.999
5ht2b_human 99 2.49x49 TM2 A => D missense 8.24e-06 1 121364 0 0.0 1.0
5ht2b_human 94 2.44x44 TM2 M => T missense 2.472e-05 3 121382 0 0.02 0.024
5ht2b_human 93 2.43x43 TM2 L => P missense 8.238e-06 1 121384 0 0.0 1.0
5ht2b_human 92 2.42x42 TM2 F => V missense 8.238e-06 1 121390 0 0.0 1.0
5ht2b_human 91 2.41x41 TM2 Y => H missense 8.238e-06 1 121390 0 0.0 0.998
5ht2b_human 81 1.59x59 TM1 L => P missense 3.295e-05 4 121396 0 0.0 0.984
5ht2b_human 79 1.57x57 TM1 V => D missense 8.237e-06 1 121402 0 0.0 0.992
5ht2b_human 75 1.53x53 TM1 V => A missense 1.647e-05 2 121402 0 0.0 0.999
5ht2b_human 69 1.47x47 TM1 I => T missense 8.237e-06 1 121398 0 0.0 0.662
5ht2b_human 65 1.43x43 TM1 I => M missense 8.237e-06 1 121402 0 0.01 0.987
5ht2b_human 63 1.41x411 TM1 M => R missense 9.885e-05 12 121400 0 0.01 0.125
5ht2b_human 59 1.37x38 TM1 L => R missense 8.237e-06 1 121398 0 0.0 0.999
5ht2b_human 56 1.34x35 TM1 W => R missense 1.647e-05 2 121400 0 0.0 0.999
5ht2b_human 54 1.32x33 TM1 L => R missense 8.237e-06 1 121400 0 0.03 0.461
5ht2b_human 54 1.32x33 TM1 L => V missense 4.942e-05 6 121402 0 0.21 0.004
5ht2b_human 53 1.31x32 TM1 K => E missense 8.237e-06 1 121400 0 0.23 0.002
5ht2b_human 51 N-term G => E missense 0.007002 850 121400 32 0.19 0.015
5ht2b_human 49 N-term E => K missense 1.647e-05 2 121400 0 0.08 0.046
5ht2b_human 48 N-term E => D missense 8.237e-06 1 121400 0 0.11 0.015
5ht2b_human 47 N-term V => A missense 3.295e-05 4 121400 0 0.56 0.0
5ht2b_human 45 N-term Q => E missense 2.471e-05 3 121398 0 0.22 0.003
5ht2b_human 43 N-term M => V missense 6.59e-05 8 121398 0 0.22 0.036
5ht2b_human 42 N-term E => D missense 2.471e-05 3 121398 0 0.31 0.002
5ht2b_human 39 N-term I => V missense 8.237e-06 1 121400 0 nan 0.0
5ht2b_human 36 N-term T => S missense 0.0001071 13 121400 0 nan 0.001
5ht2b_human 35 N-term Q => H missense 0.0001071 13 121396 0 nan 0.188
5ht2b_human 31 N-term W => R missense 0.005322 646 121394 22 nan 0.0
5ht2b_human 27 N-term I => N missense 8.238e-06 1 121388 0 nan 0.034
5ht2b_human 27 N-term I => L missense 1.648e-05 2 121386 0 nan 0.0
5ht2b_human 26 N-term V => I missense 1.648e-05 2 121384 0 nan 0.0
5ht2b_human 25 N-term H => D missense 8.238e-06 1 121382 0 nan 0.0
5ht2b_human 23 N-term F => L missense 8.239e-06 1 121368 0 nan 0.0
5ht2b_human 22 N-term T => A missense 8.24e-06 1 121362 0 nan 0.005
5ht2b_human 16 N-term E => Q missense 8.243e-06 1 121314 0 nan 0.154
5ht2b_human 7 N-term V => M missense 8.258e-06 1 121102 0 1.0 0.0
5ht2b_human 6 N-term R => S missense 8.258e-06 1 121094 0 nan 0.024
5ht2b_human 5 N-term Y => S missense 0.0001239 15 121058 0 nan 0.245
5ht2b_human 4 N-term S => F missense 8.263e-06 1 121026 0 nan 0.007


Residue

Diagrams

ICL1 K K L Q ICL1ECL1 E A M W P L ECL1ICL2 P I Q A N Q Y N ICL2ECL2 I E T D V D N P N N I T C V L T K E R ECL2ICL3 P Q R L T W L T V S T V F Q R D E T P C S S P E K V A M L D G S R K D K A L P N S G D E T L M R R T S T I G K K S ICL3ECL3 D S C ECL3N-term M A L S Y R V S E L Q S T I P E H I L Q S T F V H V I S S N W S G L Q T E S I P E E M K Q I V E E Q G N N-termC-term T C N Y R A T K S V K T L R K R S S K I Y F R N P M A E N S K F F K K H G I R N G I N P A M Y Q S P M R L R S S T I Q S S S I I L L D T L L L T E N E G D K T E E Q V S Y V C-term K L H W A A L L I L M V I I P T I G G N T L V I L A V S L E Y A T N Y F L M S L A V A D L L V G L F V M P I A L L T I M F P L V L C P A W L F L D V L F S T A S I M H L C A I S V D R Y I A I K K S R A T A F I K I T V V W L I S I G I A I P V P I K G F G D F M L F G S L A A F F T P L A I M I V T Y F L T I H A L Q K K A Y L V K N K P V Q T I S N E Q R A S K V L G I V F F L F L L M W C P F F I T N I T L V L C N Q T T L Q M L L E I F V W I G Y V S S G V N P L V Y T L F N K T F G R F R D A Y I
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